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These areMini-ITX,MicroATX,ATX, andE-ATX.
The most common motherboard size is ATX, which measures 12 x 9.6 inches.
As a frame of reference, Mini-ITX is around two-thirds the size of an ATX motherboard.
Historically, the former was designed for lower power consumption and efficiency when compared to the more common sizes.
If so, maybe the silicon needs to be larger.
It will ultimately depend on the use case.
Do you need more expansion slots?
Which motherboard should you buy?
Consider the chipset of the board for starters.
Will you use AMD’s AM4 or AM5 platform?
All four motherboard sizes support the latest and greatest of today’s processor technology, just in different ways.
Compatibility is the most important factor above all.
The motherboard is the foundation of your whole machine, after all.